Discussion Questions Essay Example | Topics and Well Written Essays - 750 words

Discussion Questions - Essay Example 2006 posited that the key to leadership is ‘the discipline to prioritize and the ability to work toward a stated goal’ (p.30). Hitler was certainly able to work toward his set goal. A scenario in which this style would be best suited would be the one in which members of a community are experiencing prejudicial treatment because of the color of their skin or their ethnic background. There may be a situation where individuals from a particular community are constantly being the subject to racial attacks via the media and through face-to-face interactions. One individual can arise from the group who has the qualities of a charismatic leader. This individual can influence based on his/her charm, the majority of the community members to take a specific stand against the injustice. The charismatic leader suits this scenario because in the case of discrimination, it takes someone who would be respected and revered by all to make a difference. Not only must this individual be respected by the community in which he /she belongs but also by the community that is meting out the injustices. Change is inevitable and although people are naturally resistant to change the author of this paper believes that the following strategies as cited by Kotelnikov 2008 would be effective in dealing with dissent and resistance: An employee who refuses to change after being invited to participate in the change process and after all the above strategies have been attempted would have to be directed to another organization. This individual would only hinder rather than help the new initiatives of the organization to go forward. The length of time such an individual would remain in the organization would therefore depend on the length of time it takes to complete each of the strategies decided as best by the organization to deal with resistance to change. Musser, S.J. (1987). The determination of positive and negative charismatic leadership, Retrieved February 20, 2008 from

What is the current status of clinical gene therapy trials for Chronic Essay

What is the current status of clinical gene therapy trials for Chronic Granulomatous Disorder - Essay Example ests that the disease is present in ‘one in 250,000’ infants at birth, but the symptoms become evident only when the child reaches a few months of age (Assari 2006: 6). Only 21% of patients have survived the disease beyond the age of 7 previously, whereas the recent trends show improvement in the survival rates because of the ‘advancement in treatments’ (Assari 2006: 6). On the other hand, the disease can rarely occur in adults, and therefore, if someone has the problem of ‘recurrent infections’, it will be advisable to subject such individuals to an evaluation, irrespective of the age factor (Chung, Cyr & Ellis 2013: 2). Gene therapy, which is the intervention in a disease or disorder through introducing genes into the affected cells to set right the impacts of ‘specific gene mutations’, is one of the methods used in the treatment of CGD (Dugal & Chaudhary 2012: 4). However, evidence suggests that in order for the treatment to be effective, the appropriate gene will have to be incorporated into the target cell ‘specifically, efficiently and stably’ (Dugal & Chaudhary 2012: 4). On the other hand, it is also necessary to use the most appropriate vector for the introduction of the gene or gene delivery into the human cell. Research studies have identified lentiviral vectors (LVs) to be one of the effective and the ‘most widely used’ vectors in gene therapy (Dugal & Chaudhary 2012: 4). A study conducted by Assari (2006: 6) on mice found that gene therapy, using recombinant retroviral vectors, is an effective treatment for the reconstruction of normal neutrophils an d in building ‘resistance to pathogens’ such as Aspergillus. The author also contends that gene therapy, using retroviral vectors in two humans, has produced ‘encouraging results’ where both of them have attained remarkable levels of gene corrected cells and their clinical conditions show good improvement (Assari 2006: 6). Studies further substantiate the fact that gene